Ani Flexi+
GameDog AniFlexi+ for healthy joints and spine
– Relieves symptoms of osteoarthritis
- Reduces joint inflammation
- Alleviates pain
- Provides chondroprotective effects
- Improves joint mobility and flexibility
- Inhibits the progression of joint and spinal degeneration (spondylosis)
- Nourishes the body's cartilage
- Relieves symptoms of collapsing trachea
- Supports puppies with joint cartilage developmental issues
Packaging: 150 g, 250 g, 500 g
Price range: 33.99 € through 72.00 €
AniFlexi + is an innovative, multi-ingredient veterinary dietary supplement for dogs, designed to support the proper function of the locomotor system. The active ingredients reduce inflammation and pain in the cartilage, while improving joint flexibility and mobility. Regular use has a positive effect on the musculoskeletal system and helps prevent degenerative joint changes.
Recommended for Animals with degenerative joint and spinal diseases, senior dogs, and young dogs during periods of intensive growth with developmental cartilage irregularities.
Why choose GameDog AniFlexi+
- Supports the treatment of hip and joint dysplasia
- Inhibits the progression of joint and spinal degeneration (spondylosis)
- Improves joint mobility and flexibility
- Supports puppies with joint cartilage developmental issues
- Relieves symptoms of collapsing trachea
- Reduces pain
- Nourishes cartilage tissues throughout the body
Quality: All ingredients in Game Dog Performance Nutrition products are of the highest quality and meet Human Grade standards.
The advanced veterinary formula is based on the highest quality active ingredients: :
OmniCol™ hydrolyzed collagen (<2500 Daltons) – nourishes and supports the regeneration of joints and other connective tissues in the body. It provides free amino acids, peptides, and collagen fibers necessary for collagen synthesis within the body [1]. Due to its low molecular weight, it offers higher bioavailability and superior bioactive properties [2]. Regular supplementation improves joint mobility and flexibility and visibly reduces pain in degenerative joint and spinal diseases [3,4,5]. (<2500 Daltonov) - nourishes and supports the regeneration of joints and other connective tissues in the body. It provides free amino acids, peptides, and collagen fibers necessary for collagen synthesis in the body. Due to its low molecular weight, it has higher bioavailability and better bioactive properties. Regular supplementation improves joint mobility and flexibility and visibly reduces pain in degenerative joint and spine diseases.
Natural Type II Collagen T2NDC® – through the mechanism of oral tolerance, it triggers anti-inflammatory and protective pathways for the cartilage, thereby reducing joint pain and inflammation [6,7,8]. It accelerates recovery after surgical treatment of cruciate ligament injuries in dogs [9]. Natural Type II Collagen T2NDC® –
Hyaluronic Acid Ensures proper viscosity and elasticity of the synovial fluid in the joint capsule, thereby increasing joint flexibility and improving mobility [10,11,12].
Boswellia Serrata Alleviates skeletal system issues by improving joint blood circulation, while also reducing swelling, inhibiting inflammation, and relieving joint pain [13,14].
MSM (Methylsulfonylmethane) – an organic sulfur compound that supports joint regeneration and reduces pain. It has a powerful anti-inflammatory effect and promotes the health of cartilage and connective tissues [15].
Glucosamine: Actively participates in the synthesis of glycosaminoglycans (GAGs) [16]. It promotes cartilage regeneration and proper joint function. It increases the amount of synovial fluid in the joint capsule, significantly reducing pain and facilitating movement [15,16,17,18].
Chondroitin Sulfate Improves the elasticity of cartilage tissue and reduces painful joint swelling [17, 20]. It stimulates the biosynthesis of hyaluronic acid and proteoglycans, which give cartilage its elasticity and resistance to deformation [21].
Vitamin C: Stimulates the synthesis of proteoglycans, is essential for the formation and secretion of ossein (the building block of bone), accelerates collagen synthesis processes, and prevents its degradation in the body [22].
Available sizes: 150g, 250g, 500g
Recommended for Animals with degenerative diseases of the joints and spine, as well as young dogs during periods of intensive growth who exhibit abnormalities in the development of joint cartilage.
- Supports the treatment of joint dysplasia.
- Inhibits the progression of joint and spinal degeneration (spondylosis)
- Improves joint mobility and flexibility
- Supports puppies with abnormalities in joint cartilage development.
- Relieves symptoms of collapsing trachea
- Reduces pain
- Nourishes the cartilage within the body.
| Active Ingredients |
Content per 1 g |
| Hydrolyzed Collagen | 500 mg |
| T2NDC® Type II Collagen | 10 mg |
| Hyaluronic Acid | 10 mg |
| Glucosamine Sulfate | 200 mg |
| Chondroitin Sulfate | 100 mg |
| Boswellia Serrata | 100 mg |
| MSM (Methylsulfonylmethane) | 50 mg |
| Vitamin C: | 30 mg |
Composition
Hydrolyzed collagen (bovine) 50%, glucosamine sulfate (from marine crustaceans) 20%, chondroitin sulfate (bovine) 10%, methylsulfonylmethane (MSM) 5%, sodium hyaluronate 1%, undenatured type II collagen 1%.
Additives (g/kg)
Vitamin C (L-ascorbic acid)
Sensory additives (g/kg)
Boswellia serrata extract (boswellic acid – 65%)
Analytical Constituents
- Crude protein 58%
- Crude fat 0,5%
- Crude fibers 0,5%
- Crude ash 9%
Measuring scoop contains:
1,5 g (AniFlexi+ 150 g), 5 g (AniFlexi+ 250 g, AniFlexi+ 500 g) izdelka$\rightarrow$ 1.5 g (AniFlexi+ 150 g), 5 g (AniFlexi+ 250 g, AniFlexi+ 500 g) of product
Support for joint dysfunction:
5 kg dogs: 1 g
10 kg dogs: 1.5 g
30 kg dogs 5 g
5 g (1 scoop) for every 30 kg of the dog's body weight for at least 30 days or until symptoms subside.
Afterward, the dose can be reduced to 2.5 g (1/2 scoop) for every 30 kg of body weight.
Mix the portion of the product with food before serving.
What is the difference between AniFlexi+ and AniFlexi HA?
Both products are designed for dogs with diagnosed musculoskeletal issues. AniFlexi HA comes in tablet form, while AniFlexi+ is a powder. AniFlexi+ contains two additional ingredients: Boswellia Serrata and natural type II collagen, making it an excellent choice for dogs with advanced musculoskeletal diseases.
Is this product suitable for puppies?
he product is safe for puppies and is an excellent choice for musculoskeletal conditions in growing dogs. However, if the puppy is healthy and shows no issues, we highly recommend AniFlexi Fit – a product specifically designed to support musculoskeletal development in puppies.
Can this product be dissolved in water?
Absolutely. AniFlexi+ dissolves perfectly in water, but you should use lukewarm or cold water. For better taste, it can also be mixed with an egg or animal fat.
Should I take a break from using the product?
We do not recommend interrupting the use of this product.
AniFlexi + is an innovative, multi-ingredient veterinary dietary supplement for dogs, designed to support the proper function of the locomotor system. The active ingredients reduce inflammation and pain in the cartilage, while improving joint flexibility and mobility. Regular use has a positive effect on the musculoskeletal system and helps prevent degenerative joint changes.
Recommended for Animals with degenerative joint and spinal diseases, senior dogs, and young dogs during periods of intensive growth with developmental cartilage irregularities.
Why choose GameDog AniFlexi+
- Supports the treatment of hip and joint dysplasia
- Inhibits the progression of joint and spinal degeneration (spondylosis)
- Improves joint mobility and flexibility
- Supports puppies with joint cartilage developmental issues
- Relieves symptoms of collapsing trachea
- Reduces pain
- Nourishes cartilage tissues throughout the body
Quality: All ingredients in Game Dog Performance Nutrition products are of the highest quality and meet Human Grade standards.
The advanced veterinary formula is based on the highest quality active ingredients: :
OmniCol™ hydrolyzed collagen (<2500 Daltons) – nourishes and supports the regeneration of joints and other connective tissues in the body. It provides free amino acids, peptides, and collagen fibers necessary for collagen synthesis within the body [1]. Due to its low molecular weight, it offers higher bioavailability and superior bioactive properties [2]. Regular supplementation improves joint mobility and flexibility and visibly reduces pain in degenerative joint and spinal diseases [3,4,5]. (<2500 Daltonov) - nourishes and supports the regeneration of joints and other connective tissues in the body. It provides free amino acids, peptides, and collagen fibers necessary for collagen synthesis in the body. Due to its low molecular weight, it has higher bioavailability and better bioactive properties. Regular supplementation improves joint mobility and flexibility and visibly reduces pain in degenerative joint and spine diseases.
Natural Type II Collagen T2NDC® – through the mechanism of oral tolerance, it triggers anti-inflammatory and protective pathways for the cartilage, thereby reducing joint pain and inflammation [6,7,8]. It accelerates recovery after surgical treatment of cruciate ligament injuries in dogs [9]. Natural Type II Collagen T2NDC® –
Hyaluronic Acid Ensures proper viscosity and elasticity of the synovial fluid in the joint capsule, thereby increasing joint flexibility and improving mobility [10,11,12].
Boswellia Serrata Alleviates skeletal system issues by improving joint blood circulation, while also reducing swelling, inhibiting inflammation, and relieving joint pain [13,14].
MSM (Methylsulfonylmethane) – an organic sulfur compound that supports joint regeneration and reduces pain. It has a powerful anti-inflammatory effect and promotes the health of cartilage and connective tissues [15].
Glucosamine: Actively participates in the synthesis of glycosaminoglycans (GAGs) [16]. It promotes cartilage regeneration and proper joint function. It increases the amount of synovial fluid in the joint capsule, significantly reducing pain and facilitating movement [15,16,17,18].
Chondroitin Sulfate Improves the elasticity of cartilage tissue and reduces painful joint swelling [17, 20]. It stimulates the biosynthesis of hyaluronic acid and proteoglycans, which give cartilage its elasticity and resistance to deformation [21].
Vitamin C: Stimulates the synthesis of proteoglycans, is essential for the formation and secretion of ossein (the building block of bone), accelerates collagen synthesis processes, and prevents its degradation in the body [22].
Available sizes: 150g, 250g, 500g
Recommended for Animals with degenerative diseases of the joints and spine, as well as young dogs during periods of intensive growth who exhibit abnormalities in the development of joint cartilage.
- Supports the treatment of joint dysplasia.
- Inhibits the progression of joint and spinal degeneration (spondylosis)
- Improves joint mobility and flexibility
- Supports puppies with abnormalities in joint cartilage development.
- Relieves symptoms of collapsing trachea
- Reduces pain
- Nourishes the cartilage within the body.
| Active Ingredients |
Content per 1 g |
| Hydrolyzed Collagen | 500 mg |
| T2NDC® Type II Collagen | 10 mg |
| Hyaluronic Acid | 10 mg |
| Glucosamine Sulfate | 200 mg |
| Chondroitin Sulfate | 100 mg |
| Boswellia Serrata | 100 mg |
| MSM (Methylsulfonylmethane) | 50 mg |
| Vitamin C: | 30 mg |
Composition
Hydrolyzed collagen (bovine) 50%, glucosamine sulfate (from marine crustaceans) 20%, chondroitin sulfate (bovine) 10%, methylsulfonylmethane (MSM) 5%, sodium hyaluronate 1%, undenatured type II collagen 1%.
Additives (g/kg)
Vitamin C (L-ascorbic acid)
Sensory additives (g/kg)
Boswellia serrata extract (boswellic acid – 65%)
Analytical Constituents
- Crude protein 58%
- Crude fat 0,5%
- Crude fibers 0,5%
- Crude ash 9%
Measuring scoop contains:
1,5 g (AniFlexi+ 150 g), 5 g (AniFlexi+ 250 g, AniFlexi+ 500 g) izdelka$\rightarrow$ 1.5 g (AniFlexi+ 150 g), 5 g (AniFlexi+ 250 g, AniFlexi+ 500 g) of product
Support for joint dysfunction:
5 kg dogs: 1 g
10 kg dogs: 1.5 g
30 kg dogs 5 g
5 g (1 scoop) for every 30 kg of the dog's body weight for at least 30 days or until symptoms subside.
Afterward, the dose can be reduced to 2.5 g (1/2 scoop) for every 30 kg of body weight.
Mix the portion of the product with food before serving.
What is the difference between AniFlexi+ and AniFlexi HA?
Both products are designed for dogs with diagnosed musculoskeletal issues. AniFlexi HA comes in tablet form, while AniFlexi+ is a powder. AniFlexi+ contains two additional ingredients: Boswellia Serrata and natural type II collagen, making it an excellent choice for dogs with advanced musculoskeletal diseases.
Is this product suitable for puppies?
he product is safe for puppies and is an excellent choice for musculoskeletal conditions in growing dogs. However, if the puppy is healthy and shows no issues, we highly recommend AniFlexi Fit – a product specifically designed to support musculoskeletal development in puppies.
Can this product be dissolved in water?
Absolutely. AniFlexi+ dissolves perfectly in water, but you should use lukewarm or cold water. For better taste, it can also be mixed with an egg or animal fat.
Should I take a break from using the product?
We do not recommend interrupting the use of this product.
Collagen and its derivatives: from structure and properties to their applications in the food industry. Food Hydrocoll. 2022, 131, 107748. Zhou K., Zhu Y., Zhang W., Xie Y., Wang Z., Zhou H., Yang T., Zhang Q., Xu B. Kolagen in njegovi derivati : od strukture in lastnosti do njihove uporabe v živilski industriji . Hrana Hydrocoll . 2022, 131, 107748.
2. Hong H., Fan H., Chalamaiah M., Wu J. Preparation of low-molecular-weight collagen hydrolysates (peptides): Current progress, challenges, and future perspectives. Food Chem. 2019, 301, 125222. 3. Weide N. Use of gelatin hydrolysate in clinically orthopedically healthy dogs and dogs with chronic diseases of the musculoskeletal system. Doctoral thesis. University of Veterinary Medicine Hannover, 2004. 4. Hesse, K. J. F. Collagen hydrolysate supplementation in dogs suffering from osteoarthritis. Kleintiermedizin. 2006, 9, 17-22. 5. Bello AE, Oesser S. Collagen hydrolysate for the treatment of osteoarthritis and other joint diseases: a review of the literature. Curr Med Res Opin. 2006 Nov;22(11):2221-32. 6. Deparle LA, Gupta RC, Canerdy TD, Goad JT, D’Altilio M., Bagchi M., Bagchi D. Efficacy and safety of glycosylated undenatured type II collagen (UC-II) in the therapy of arthritic dogs. J. Vet. Pharmacol. Ther. 2005, 28, 385–390. 7. Zapata A., Fernández-Parra R. Management of Osteoarthritis and Joint Support Using Feed Supplements: A Scoping Review of Undenatured Type II Collagen and Boswellia serrata. Animals 2023, 13, 870. 8. D’Altilio M., Peal A., Alvey M., Simms C., Curtsinger A., Gupta RC, Canerdy TD, Goad JT, Bagchi M., Bagchi D. Therapeutic Efficacy and Safety of Undenatured Type II Collagen Alone or in Combination with Glucosamine and Chondroitin in Arthritic Dogs. Toxicol. Mech. Methods 2007, 17, 189–196. 9. Assies M., Berger B., Stegen B., Bottcher P. Undenatured type 2 collagen – Effects on recovery and osteoarthritis progression after TPLO in dogs. A prospective, blinded and randomized study. Esvot Virtual Congress, 2021. 10. Evanko SP, Tammi MI, Tammi RH, Wight TN. Hyaluronan-dependent pericellular matrix. Adv. Drug Deliv. Rev. 2007, 59, 1351–1365. 11. Plickert H., Bondzio A., Einspanier R., Tichy A., Brunnberg L. Hyaluronic acid concentrations in synovial fluid of dogs with different stages of osteoarthritis. Res. Vet. Sci. 2013, 94, 728–734. 12. Serra Aguado CI, Ramos-Plá JJ, Soler C., Segarra S., Moratalla V., Redondo JI. Effects of Oral Administration of Hyaluronic Acid in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury. Animals (Basel). 2021 Apr 27;11(5):1264. 13. Reichling J., Schmökel H., Fitzi J., Bucher S., Saller R. Dietary support with Boswellia resin in canine inflammatory joint and spinal disease. Schweiz Arch Tierheilkd. 2004 Feb;146(2):71-9. 14. Martello E., Bigliati M., Adami R., Biasibetti E., Bisanzio D., Meineri G., Bruni N. Efficacy of a dietary supplement in dogs with osteoarthritis: A randomized, placebo-controlled, double-blind clinical trial. PLoS One. 2022 Feb 16;17(2):e0263971. 15. Pagonis T., Givissis P., Kritis A., Christodoulou A. The effect of methylsulfonylmethane on osteoarthritic large joints and mobility. International Journal of Orthopedics, 2014. 1. 1-6. 16. Henrotin Y., Mobasheri A., Marty M. Is there any scientific evidence for the use of glucosamine in the treatment of human osteoarthritis? Arthritis Res Ther. 2012;14(1):201. 17. Jerosch J. Effects of Glucosamine and Chondroitin Sulfate on Cartilage Metabolism in OA: Outlook on Other Nutrient Partners Especially Omega-3 Fatty Acids. Int. J. Rheumatol. 2011;2011:969012. 18. Dodge GR, Regatte RR, Noyszewski EA, Hall JO, Sharma AV, Callaway DA, Reddy R. The Fate of Oral Glucosamine Traced by (13)C Labeling in the Dog. Cartilage. 2011 Jul;2(3):279-85. 19. Wenz W., Hornung C., Cramer C., Schroeder M., Hoffmann M. Effect of Glucosamine Sulfate on Osteoarthritis in the Cruciate-Deficient Dog Model of Osteoarthritis. Cartilage. 2017 Apr;8(2):173-179. 20. McCarthy G., O’Donovan J., Jones B., McAllister H., Seed M., Mooney C. Randomised double-blind, positive-controlled trial to assess the efficacy of glucosamine/chondroitin sulfate for the treatment of dogs with osteoarthritis. Vet J. 2007;174(1):54-61. 21. Iovu M., Dumais G., du Souich P. Anti-inflammatory activity of chondroitin sulfate. Osteoarthritis Cartilage 2008;16(Suppl 3):S14–S18. 22. Ripani U, Manzarbeitia-Arroba P, Guijarro-Leo S, Urrutia-Graña J, De Masi–De Luca A. Vitamin C may help to reduce the knee arthritic symptoms. Outcomes assessment of nutraceutical therapy. Med Arch. 2019 Jun;73(3):173-177. , Fan H., Chalamaiah M., Wu J. Priprava nizkomolekularnih kolagenskih hidrolizatov ( peptidov ): Trenutni napredek, izzivi in prihodnje perspektive . Food Chem. 2019, 301, 125222.
3. Weide N. Der Einsatz von Gelatinehydrolysat bei clinicisch -orthopädisch gesunden Hunden und Hunden mitochronschen Erkrankungen des Bewegungsapparats . doktorsko delo . Tierärztliche Hochschule Hannover , 2004.
4. Hesse, K. J. F. Dodatek kolagenskega hidrolizata pri psih , ki trpijo zaradi osteoartritisa . Kleintiermedizin.2006, 9, 17-22.
5. Bello AE , Oesser S. Hidrolizat kolagena za zdravljenje osteoartritisa in drugih bolezni sklepov : pregled literature . Curr Med Res Opin. 2006 Nov;22(11):2221-32.
6.Deparle LA, Gupta RC, Canerdy TD, Goad JT, D’Altilio M., Bagchi M., Bagchi D. Učinkovitost in varnost glikoziliranega nedenaturiranega kolagena tipa II (UC-II) pri terapiji psov z artrozo . J. Vet. Pharmacol . Tam . 2005, 28, 385–390.
7. Zapata A., Fernández-Parra R. Obvladovanje osteoartritisa in podpore sklepom z uporabo prehranskih dopolnil : Pregled obsega nedenaturiranega kolagena tipa II in Boswellia serrata . Živali 2023, 13, 870.
8. D’Altilio M., Peal A., Alvey M., Simms C., Curtsinger A. , Gupta RC, Canerdy TD, Goad , JT, Bagchi M., Bagchi D. Terapevtska učinkovitost in varnost nedenaturiranega kolagena tipa II samega ali v kombinaciji z glukozaminom in hondroitinom pri artritičnih psih . Toxicol . Dol. Metode 2007, 17, 189–196.
9. Assies M., B erger B. , Stegen B. , Bottcher P. Nedenaturiran kolagen tipa 2 – Učinki na okrevanje in napredovanje osteoartritisa po TPLO pri psih . Prospekt , slepa in randomizirana študija . Virtualni kongres Esvot , 2021.
10 . Evanko SP, Tammi MI, Tammi RH, Wight TN Od hialuronana odvisen pericelularni matriks. Adv . Zdravilo Deliv . Rev. 2007, 59, 1351–1365.
1 1 . Plickert H., Bondzio A., Einspanier R. , Tichy A., Brunnberg , L. Koncentracije hialuronske kisline v sinovialni tekočini psov z različnimi stopnjami osteoartritisa . Res. Veteran . Sci . 2013, 94, 728–734.
1 2 . Serra Aguado CI, Ramos -Plá JJ, Soler C., Segarra S., Moratalla V., Redondo JI Učinki peroralnega dajanja hialuronske kisline pri psih po operaciji napredovanja tibialne tuberoznosti zaradi poškodbe kranialne križne vezi . Živali ( Basel ). 2021 27. april ;11(5):1264.
1 3 . Reichling J., Schmökel H., Fitzi J., Bucher S., Saller R. Prehranska podpora s smolo Boswellia pri pasji vnetni bolezni sklepov in hrbtenice . Schweiz Arch Tierheilkd . 2004, februar; 146 (2): 71-9.
1 4 . Martello E., Bigliati M., Adami R., Biasibetti E., Bisanzio D., Meineri G., Bruni N. Učinkovitost prehranskega dopolnila pri psih z osteoartritisom : randomizirano, s placebom kontrolirano , dvojno slepo klinično preskušanje . PLoS One. 16. februar 2022 ; 17 (2 ): e 0263971.
1 5 . Pagonis , Thomas & Givissis , Panagiotis & Kritis , Aristeidis & Christodoulou , Anastasios . Učinek metilsulfonilmetana na osteoartritične velike sklepe in gibljivost . International Journal of Orthopedics , 2014. 1. 1-6.
1 6 . Henrotin Y., Mobasheri A. , Marty M. Ali obstajajo znanstveni dokazi za uporabo glukozamina pri zdravljenju osteoartritisa pri ljudeh ? Artritis Res Ther . 2012; 14 (1): 201.
1 7 . Jerosch J. Učinki glukozamina in hondroitin sulfata na presnovo hrustanca pri OA: pogled na druge hranilne partnerje , zlasti omega-3 maščobne kisline . Int . J. Rheumatol . 2011;2011:969012 .
1 8 . Dodge GR, Regatte RR, Noyszewski EA, Hall JO, Sharma AV, Callaway DA, Reddy R. Usoda oralnega glukozamina , ki ga sledi označevanje (13)C pri psu. hrustanec . 2011 julij;2(3):279-85.
1 9 . Wenz W., Hornung C., Cramer C., Schroeder M., Hoffmann M. Učinek glukozamin sulfata na osteoartritis pri modelu osteoartritisa pri psih s pomanjkanjem križa . hrustanec . 2017 Apr;8(2):173-179.
20 . McCarthy G., O’Donovan J., Jones B., McAllister H. , Seed M. , Mooney C. Randomizirano dvojno slepo , pozitivno kontrolirano preskušanje za oceno učinkovitosti glukozamina / hondroitin sulfata za zdravljenje psov z osteoartritisom . Vet J. 2007; 174 (1): 54-61.
2 1 . Iovu M., Dumais G. , du Souich P. Protivnetna aktivnost hondroitin sulfata . Osteoartritis hrustanec 2008; 16 ( dodatek 3 ): S 14–S18
2 2 . Ripani U, Manzarbeitia-Arroba P, Guijarro -Leo S, Urrutia-Graña J, De Masi – De Luca A. Vitamin C lahko pomaga zmanjšati artritične simptome kolena . Ocena rezultatov prehranske terapije . Med Arh. 2019 Jun;73(3):173-177.
Max is a working-line German Shepherd and holds a very special place in our family.
He has been our companion for eleven years now.
We were heartbroken when he started showing weakness in his hindquarters and began rising very slowly from a lying position.
Now, we regularly give him the AniFlexi+ supplement, and the change is remarkable.
He has become lively again and is back to his old mischievous self.
Mira from Trbovlje
